I tried a poisoner, and it takes patience. Similar, I experimented a lot with a poisoner in game, and learned first hand that there are tons of creative ways to take down any class in the game.

The player who likes a poisoner or a trapper will be the kind that sees a tall ceiling to his potential depending on what he can find and how clever he is. A few folks already spelled out some strategies.

A successful poisoner will know about lots of different bad foods, cursed weapons, and other things all over thera he can Suggest a target to wear.

Push and thief waylay can help you get suggests off. You can jack a person, then while they are sleeping apply inhaled. yep. Think of what you could do with that!

Powerful neuro poison can cause blindness. And forget. Depending on the concoction these will flake in periodically or potentially stick around.

That said, poisoning is still hard. It takes timing, hit points (don't gear for damage) and yes luck. But what other class can get an AP to wield a cursed level 5 dagger instead of his unholy blessed axe?

That said, I vouch that poison skills are too expensive. If you go all poisoning I think it costs around 60 points. Granted, poisoners get 17 skills, way more than other paths, but still hard to work with.

I looked into a poisoner adding the basics: plant, scrolls and knife, That's 81 points. You got 19 left to get creative with. Maybe blackjack and shield block. Maybe push and thief waylay and cheap shot. Bleah, not a lot of room for creativity in the build.