Throughout my time playing this game I have come across a plethora of potions that have nothing but maledictive or harmful affects. Now these already have a niche in the game to add a little danger to trying new potions but I feel for the most part these things just sit there and gather dust.

How about adding the ability to throw potions to mages. I would restrict it to mages and perhaps high level poison thieves just to give them a little bit of an edge. Personally i think it would make a good skill, as you get better at the skill you miss less.

for coolness you could have critical failures where you spill it all over yourself or perhaps hit the wrong target.

I would consider also adjusting level of the potions magic based on the level of the mage, so a level 10 mage isn't getting the full affect of a level 51 power word kill potion. Conversly a hero mage might pump a little extra magic into that level 5 poison potion.

This little addition could add some extra nifty tactics to playing mages and could even introduce entirely new tactics, such as hurling a recall potion at an enemy. (in the case of spells that require trust I would still give a chance to hit enemies with it but give them an extra save or two). Could also be cool to hurl a teleport potion at someone.

conversly you might consider giving thug thieves or someone else a forcefeed skill where they can attempt to get sleeping victims to eat pills or other food stuffs.