The bottom line in my mind, from my perspective, is once you start extrapolating to a certain degree past what's observable you're hazarding no more of an accurate guess than religions do.

That's what it basically boils down to. You've got science, which explains observable phenomena - once you start applying it to things you can't observe you're just guessing, with no verification. To that degree, I consider myself "scientifically agnostic", I'm a "show me" type of person and I'm not going to take anything on faith because I feel no need to. If its not something we can readily explain and observe - what use is there in taking the guesses so seriously? Hence, its an interesting starting point, but I take it no more dogmatically than that.