You have to be able to see the orb to hold it. For some characters, that's not an option even if they can see it. Eg an ap with iron grip on 2h weapon, someone who has those items webbed and is being tripped, someone who is permalagged (since otherwise an ally could send you home). Orbs can be stolen.

Not to mention that the damage from insects is itself quite significant and you can't grab any sleep near the ticks. So that means having healing on hand. That means not being too dex maladicted or having little else in your inventory.

Btw my current I'd probably something like 130 - 3 in pk (at a guess) despite having no enemies on 50 percent of the time. I have no issues with sequester because you can usually just run around until it wears off. With insects the terrain and entangle/spike growth typically remove that option.